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A review on opioid induced hyperalgesia

Richard Hayashi

Animal models and healthy human volunteers have both successfully exhibited opioid-induced hyperalgesia (OIH). Remifentanil, fentanyl, morphine, and diamorphine are the opioids that were found to be potentially responsible for OIH in these experimental settings. OIH and tolerance in surgical patients have primarily been researched following opioid-based anaesthesia and also during postoperative analgesia. Because of insufficient data and contradictory findings, these findings were utilised to highlight a pathophysiological phenomenon, but the true clinical impact of OIH has never been quantified. To ascertain whether OIH has a clinical effect on patients' perception of pain following surgery, the purpose of this systematic review and meta-analysis was to analyse the available research. This systematic review's objective was to evaluate the clinical effects of intra-operative OIH in post-operative patients.