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An efficient one-pot, four-component synthesis of a series of pyrazolo [3,4- b] pyridines in the presence of magnetic LDH as a nanocatalyst.

Fatemeh Majidi Arlan*, Ramin Javahershenas, Jabbar Khalaf

 One-pot, four-component reaction of 3-aryl-3-oxopropanenitriles, 1-aryl-3-methyl-1H-pyrazol-5(4H) one, arylglyoxals and ammonium acetate using green solvent systems and different catalysts under reflux conditions afforded a series of the corresponding 4-aroyl-3-methyl-1,6-diaryl-1H-pyrazolo pyridine-5-carbonitrile derivatives. The best yields (70-85%) were obtained using magnetic LDH as a nanocatalyst in EtOH/H2O (1:1) under reflux conditions. This protocol provides mild reaction conditions, good yields, simple workup procedure, easy preparation of nanocatalyst and, products to structurally diverse bicyclic pyrazolo pyridines, which may have biological and pharmacological activities.