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Brain targeting potential of carbamazepine SNEEDS

Gannu Praveen Kumar

 The delivery of novel drug delivery systems to epileptic brain would be an attractive strategy [1]. Carbamazepine (CBZ) SNEDDS was developed using medium chain triglycerides, polysorbate 80, lecithin and ascorbyl palmitate. Ternary phase diagrams were constructed to identify the self nano-emulsified region. The SNEDDS were subjected to visual observation, size and zeta potential, scanning electron microscopic studies, Fourier transformed infrared spectroscopy, pharmacokinetics and brain distribution studies analyzed by HPLC.