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Detection of vanA, vanB, and selected virulence genes of Enterococcus faecalis isolates from Ribat University Hospital in Khartoum State

Hisham N. Altayb

 Resistance to vancomycin among enterococci is an emerging health problem worldwide. In Sudan, limited data is present about its molecular epidemiology. This study aimed to detect vanA and vanB genes, virulence factors, and antimicrobial susceptibility of Enterococcus faecalis isolated from clinical specimens in Ribat University Hospital. From a total of 46 E. faecalis investigated in this study, VanB gene was present in 10.9% of the isolates while vanA gene was not detected at all. Fifty-nine percent of the isolates had gelE gene followed by asa1 (34.8%) and hyl genes (10.9%), while cylA and esp genes were not detected at all strains. Resistance to ciprofloxacin, co-amoxiclav, ampicillin, and vancomycin was found in 63%, 56.5%, 45.7%, and 34.8% of isolates respectively, whereas only 8.7% were resistant to nitrofurantoin. Our results indicate a high frequency of E. faecalis process vancomycin resistance with vanB genotype and high frequencies of gelE, asa1, and hyl virulence genes