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Di-(2-ethylhexyl) phthalate-induced toxicity and oxidative stress in male rabbits

Fayrouz A. Khaled

About 95% of di-ethylhexylphthalate( DEHP) produced and used as a plasticizer in polyvinyl chloride (PVC) resins for fabricating flexible vinyl products. Di(2-ethylhexyl)phthalate is a well-characterized reproductive system toxicant; it is a member of the phthalate chemical family, plasticizers that have potential endocrine-disrupting effects. DEHP and its metabolites alter proper testicular development in fetal rat models. The experiment was designed to study toxic effects of Di-(2-ethylhexyl) phthalate (DEHP) on semen characteristics, testosterone levels, testicular lipid peroxidation and testicular antioxidants in male New-Zealand white rabbits for 12 weeks. Rabbits were orally administered the doses of DEHP every day for 12 weeks. Results obtained showed that DEHP significantly (P