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Heritable susceptibility to acute lymphoblastic leukemia

Muzaffar Navabi

The detection of recurrent genetic abnormalities has helped to improve individual prognosis and direct management. Traditionally, risk categorization has been focused on clinical criteria such as age, white blood cell count, and response to chemotherapy. Despite improvements in care, allogeneic stem cell transplantation combined with multi-agent chemotherapy, including vincristine, corticosteroids, and an anthracycline, remains the cornerstone of therapy for qualified patients. Patients who are elderly frequently find it difficult to adhere to such regimens and have a poor prognosis. Here, we go over the most significant.