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Kidney function, Epoxyeicosanoids and Hypertension

Hazel Green

Decreased Epoxyeicosatrienoic acid (EET) levels result in hyper-tension, renal and cardiovascular (CV) complications. A decrease in renal epoxygenase activity has been strongly linked to hypertension including salt-sensitive and angiotensin-dependent hypertension. These changes in kidney function, inflammation, vascular function, and fibrosis contribute to hypertension, renal and Cardiovascular (CV) disease progression. Angiotensin-dependent hypertension is also associated with increase in renal soluble Epoxide Hydrolase (sHE) protein expression. Again, an inability to upregulate CYP2C epoxygenases in response to a high-salt diet leads to impaired salt-sensitive and sodium excretion hypertension.