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Natural bacteriophages T4 and M13 down-regulates Hsp90 gene expression in human prostate cancer cells (PC-3) representing a potential nanoparticle against cancer

Swapnil Ganesh Sanmukh, Sergio Alexandre Alcantara Dos Santos, Sergio Luis Felisbino

Prostate cancer (PCa) is the second most diagnosed cancer in male in the western world. In about 90% of the cases, it is potentially curable if detected early and treated. But, in the advanced metastatic stage, PCa treatment options are limited and exhibit a poor prognosis. Even though, nanotechnological approaches for cancer cell detection, targeting, and killing have increased; the challenge for developing effective and safe nano-material as nanoparticle still remains. Here we would like to shed light on “Bacteriophage” the naturally available nanoparticle, which have been effectively utilized for its anti- microbial applications for different pathogens and in other fields of biomedicine.