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oxidoreductases probably causes resistance in gram negative bacteria

Malihe Mohamadkhani

Treatment of infections are caused by Gram-negative pathogens due to the limited use of antibiotics and increased resistance to drugs and their tendency to develop recurrent infections. Hence, there is increasingly urgent need to identify new goals and thereby combinations to improve anti-bacterial agents. Studying the effects of these factors on pathogenesis and antibiotic resistance is important to identify and design new effective antibacterial agents. Among these essential factors in the pathogenicity and antibiotic resistance some oxidoreductase can be mentioned(1). monooxygenases are a group of oxidoreductase enzymes. They are able to metabolize drugs and some antibiotics, such as imipenem. These enzymes probably due to the ability of oxidation of heterocyclic compounds, including some antibiotics, have a role in biotransformation, making them resistant and enduring infections. In this study, monooxygenase was studied in silico.