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Rejection of chronic transplant

Peter Yoshida

Hyperacute, acute, or chronic transplant rejection can all be categorised. Within minutes or hours of grafting, hyperacute rejection can happen and is typically brought on by particular antibodies against the transplant. Acute rejection can develop days or weeks after transplantation and is brought on by certain lymphocytes in the recipient that identify human leukocyte antigens in the transplanted tissue or organ. In addition, chronic rejection typically develops months or years after an organ or tissue donation. The immunopathogenesis of chronic rejections is primarily mediated by a number of pathways involving humoral, cellular, and chronic inflammatory responses. The discussion of chronic transplant rejection evaluation and management in this exercise emphasises the need of interprofessional team members working together to deliver well-coordinated care and improve patient outcomes.