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SARS-Cov-2 infection and Multisystem Inflammatory Syndrome in Children (MIS-C): New entity or severe form of Kawasaki disease?.

Marcos Altable, Muhammad Akram, Walaa Fikry Elbossaty

Multisystem Inflammatory Syndrome in Children (MIS-C) is a new type of serious disease that affects children in childhood and is associated with infection with SARS-CoV-2. According to current data, COVID-19 is less common in children and has a milder course. Recently, however, there has been an increase in the number of paediatric patients worldwide who have symptoms resembling Kawasaki disease after overcoming COVID-19 infection. Kawa-COVID-19 probably represents a new systemic inflammatory syndrome associated with SARS-CoV-2 (MIS-C) in children. Symptoms of Kawa-COVID-19 occur in paediatric patients approximately two weeks after SARS-CoV-2 infection, and in 50% of cases, the most common complication is myocarditis. Prognostic severe factors include patients over five years old and ferritin concentrations >1400 μg/L. Further international studies will be needed in the future to help better understand the nature of the disease.