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Scientific progresses and hones of chemotherapy resistance and drug technology in tongue cancers.

Thomas Mulder*

The primary target of metronomic chemotherapy was originally identified as endothelial cells supporting the tumour vasculature, and not the tumour cells themselves, consistent with the emerging concept of cancer as a systemic disease involving both tumour cells and their microenvironment. While anti-angiogenesis is an important mechanism of action of metronomic chemotherapy, other mechanisms, including activation of anti-tumour immunity and a decrease in acquired therapeutic resistance, have also been identified.