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The effect of 20 hydroxyeicosatetraenoic acid (20-HETE) antagonism on myocardial infarction of metabolic syndrome rats

Corinna Lozano

 20-hydroxyeicosatetraenoic acid (20-HETE) is an eicosanoid metabolite of that has a wide range of effects on the vascular system such as collateral cell growth, the vascular rebuilding of the heart. Metabolic syndrome and 20-HETE have been shown to be correlated together. There is a higher concentration of 20- HETE in Metabolic Syndrome patients. With a higher concentration of 20-HETE patients with metabolic syndrome have symptoms that are more severe. The effect of elevated 20-HETE is negative and can influence cell growth after a myocardial infarction. Myocardial Infarction (MI) is another term for a heart attack. In previous studies, it shows an MI size increases with an elevated level of 20-HETE. During the study, the metabolic syndrome rats and a control group of rats will be induced with an MI for about 30minutes.

After rats from both groups are given an MI and 20-HETE antagonist named 20-SOLA which counteracts 20-HETE levels will be given. 20-SOLA treatment was given to the rats at 48hours, 1 week and 8 weeks. The results indicated that the AMPK antibody for both total and phosphorylated showed a significant decrease in 48hour samples. 20-SOLA was found to create equilibrium in 20-HETE levels in all tissue samples and significantly more in JCR MI rats. 20-SOLA aided the decrease in ischemia for both rats, but again results indicate a more reliable significance in JCR MI rats. These findings are relevant to the epidemic of cardiovascular diseases plaguing populations globally.

This work is partly presented at 19th International Conference on Obesity, Healthcare - Nutrition & Fitness on March 18 - 19, 2019 held in New York, USA