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The intricacy of cell organization of the intima of huge conduits: center around pericyte-like cells

Isabella Gomez

Pericyte-like cells in the typical (non-atherosclerotic) intima (A–C) and in atherosclerotic plaque (D) of the human aorta. (A) Network framed by 3G5-positive cells in the subendothelial layer. Immunohistochemistry; intimal 'en face' tissue example; immunoperoxidase procedure. (B) Identification of the cell network shaped by the myofibril-like fiber containing cells in the subendothelial layer, envisioned by methods for electron microscopy (EM). (C) Gap intersection specific contact between cycles of two myofibril-like fiber containing cells is appeared by the bolt (EM). (D) Disorganization of cell network in an atherosclerotic injury (EM). Scale bars = 10 µm (A), 4 µm (B), 0.5 µm (C), 6 µm (D). (E) A schematic portrayal of the succession of occasions identifying with the modification (NI, IAL, and FS) and complete disruption (AP) of the organization shaped by intimal pericyte-like cells during the advancement of atherosclerotic sore. NI, ordinary intima; IAL, beginning atherosclerotic sore; FS, greasy streak; AP, atherosclerotic plaque.