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Amlodipine/atorvastatin has an effect on vascular function and normal lipid levels

Zhao Xin-Ke, Feng Ming-Xia, Qiao Ai-ling, Liu Kai, Zhang Xu, Li Ying-dong

Objective: To investigate whether the use of amlodipine/atorvastatin can affect vascular endothelial function as well as blood vessel elasticity and lipid level compared with hypotensor alone.

Method: There were 162 participants selected into domestic compound hypotensive tablets (Group 1), amlodipine tablets (Group 2) and amlodipine/atorvastatin group (Group 3) randomly. After 3 months, 144 participants remained. Each participant’s medical history was collected, and each participant underwent a blood biochemical examination including high-sensitivity C-Reactive Protein (hs-CRP), Flow-Mediated-Dilation (FMD) and Endothelium-Independent Dilatation (EID), and carotid-Femoral Pulse Wave Velocity (c-f PWV) before and after the 3-month follow-up period.

Results: Compared with baseline, the FMD values of all groups improved significantly. Group 3 showed the greatest difference, followed by Groups 2 and 1. In contrast, no difference in EID was noted (P>0.05 in three groups). After treatment, the c-f PWV of Groups 2 and 3 turned to be significantly better (P<0.05), while that of Group 1 did not change. There was no statistical significant difference among three groups. The lipid levels of the participants in Group 3 decreased, while those in Groups 1 and 2 did not change. The hs-CRP levels of Groups 2 and 3 decreased significantly, whereas that of Group 1 did not change.

Conclusions: In conclusion, we found that Amlodipine/atorvastatin combination pills can improve vascular endothelial function as well as vascular elasticity, and down-regulate the level of hs-CRP.