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Anti-inflammatory and analgesic activities of some novel carboxamides derived from 2-phenyl quinoline candidates

Nagy M Khalifa, Mohamed A Al-Omar, Ahmed A Abd El-Galil, Mohammed Abd El-Reheem

Quinolines and its derivatives represent a broad class of compounds, which have received considerable attention due to their wide range of pharmacological properties such as, anti-inflammatory, COX inhibitor, anticancer and analgesic. Starting from 2-phenylquinoline-4-carbohydrazide, several new 2- phenylquinoline-4-carboxamide derivatives were synthesized, characterized and screened for their analgesic and anti-inflammatory activity using peripheral analgesic activity (writhing test) and carrageenan-induced paw edema test in rats. Among these derivatives, compound 5 linked nucleoside analogue showed significant anti-inflammatory activity as that of diclofenac sodium (reference drug) in animal models of inflammation.