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Bone marrow mesenchymal stem cells overexpressing BFGF mediated the repair of chronic obstructive pulmonary disease in a rat model

Xin Gan, Y. Zhao, S. Peng, H. Wu, L. Ma, G. Wen, W. Zhang, L. Zhong

Objectives: To explore the role of basic Fibroblast Growth Factor (bFGF) overexpression in bone marrow mesenchymal stem cells on the repair of chronic obstructive pulmonary disease in rats.

Result: We found that the engrafted Bone Marrow Mesenchyme Stem Cells (BMSCs) survived in the rat lung tissues. The Oxygen Partial Pressure (PO₂) and Blood Oxygen Saturation (SaO₂) values in the Protein C (PC) group, M group, P group, and B group were lower than those in the Nucleated Cells (NC) group. The number of White Blood Cells (WBC) and Neutrophils (N) in the NC, M, P, and B groups were significantly lower than in the PC group. Emphysema was observed in the PC, M, P, and B groups. The MAN, MAA and MLI values in the M, P and B groups were improved compared to the PC group.

Conclusions: Our findings revealed that transplantation therapy using BMSCs overexpressing bFGF significantly improved the symptoms of the repair effect compared to the BMSC transplantation group in a rat model of Chronic Obstructive Pulmonary Disease (COPD).