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Design, synthesis, and structure-activity relationship of imidazolidin-2-one-1,3,5-triazine conjugates as Enterovirus 71 and Coxsackievirus A16 Inhibitor

Wen-li Gao, Jing-xiu Li

Aim: All microbes (e.g., bacteria, fungi, virus, and parasite) capable of infection have coupled with high levels of multidrug resistance (MDR) which leads to the significant morbidity and mortality. The present study deals with the development of novel imidazolidin-2-one-1,3,5-triazine conjugates via facile synthetic route.

Methods: The structure of the target derivatives were ascertained by using various spectroscopic analyses. These compounds were assessed for the determination of inhibitory activity against Enterovirus 71 and Coxsackievirus A16.

Result: The results of the investigation revealed that, entire set of target derivatives showed considerable inhibition against both the tested virus in plaque reduction inhibitory assay with no cytotoxicity.

Conclusion: All target derivatives were synthesized and showed considerable inhibition against both the tested virus along with no cytotoxicity.