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Docking analysis of some flavanols as Cdk-4 inhibitor as a possible option to treat retinoblastoma

Ye-ping Han, Ru-wei Chen, Feng Zhao

In present scenario, the developing economies are struggling with the burden of various forms of cancers. Among them, the heritable form of Retinoblastoma (RB) also known as common intraocular malignancy is considered as a most severe form of cancer affecting mainly children’s. Due to involvement of Cyclin Dependent Kinases (Cdks) in the phosphorylation step, its inhibition offers selective advantage in the prevention of tumour progression by activating the suppressor activity of RB protein. Encouraged by the above, the present study was intended to elucidate the effect of some which are well known for its anticancer potential on the CDK-4 with the help of molecular docking analysis.