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Effect of fermented citrullus vulgaris (ogiri) on hepatic functions in albino wistar rats.

Chike CPR, Onyebuenyi Maureen*, Bestman Njoku

This study investigated the effects of fermented Citrullus Vulgaris (Ogiri), food condiments/ spices on hepatic functions using albino wistar rats. Ogiri was produced from Citrullus Vulgaris, a type of melon seeds following the traditional fermentation process, while online monitoring was used to evaluate microbial, hazards using standard microbiological techniques. Biochemical analysis was carried out using mindray auto – analyzer method (model: bs – 800 ms).The results by the 7th day of administration of Ogiri shows that, it increased 100 mg/kg dose-289.33U/L increased liver enzymes ALT significantly (p<0.05), while 200 mg/kg-77U/L, 400 mg/kg-78U/L doses reduced the liver enzyme when compared to the control 208.67U/L. AST was reduced at all doses of ogiri administered.100 mg/kg-1477.67U/L, 200 mg/kg-417.33, 400 mg/kg-451.33U/L. By the 14th day, administration of Ogiri decreased alanine amino transferase levels (p<0.01). Aspartate transaminase and albumin showed significant increase (p<0.05). By the 28th day, test group I-X values for aspartate transaminase decreased significantly (p<0.05) from the control group 1, increase in alkaline phosphatase levels was more significant p<0.05 in test group III (Ogiri 200 mg/kg). Knorr 100 mg/kg and the synergestic dose 400 mg/kg of extracts decreased albumin levels (p<0.05) respectively when compared to the control value of enzymes. The use of Ogiri overtime is reported to be among the predisposing factors to the impairment of liver functions in rats. From the result of this study, significant differences in the serum levels of Aspartate transaminase (AST), Alanine transaminase (ALT), alkaline phosphatase (ALP), albumin, total protein and blood urea nitrogen (BUN), creatinine, sodium bicarbonate to the control indicate that the absorbed constituents of extracts and its metabolites might have reacted and interacted with the hepatic cells and renal tissues to impair liver function.From this study, the significant difference in AST and total protein as compared to the control is an indication of hepato-cellular liver disease.