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Effect of Ginkgo biloba extracts on preventing and curing wistars cerebral angiospasm after subarachnoid haemorrhage

Minjing Zuo, Wei Tu, Jianming Zhu, Zhihua Chen, Shuxin Song

Objective: To study the preventive and therapeutic effect of Ginkgo biloba extract on wistar’s cerebral angiospasm of different phases.

Method: Double cisterna magna blood injection method was adopted to set up Wistar SAH model. Then, 56 healthy male SD wistars were divided into 7 groups according to each time point (sham operation group, SAH 3d group, SAH 5 d group, SAH 7 d group, Ginkgo biloba extract 3 d group, Ginkgo biloba extract 5 d group, and Ginkgo biloba extract 7d group). Ginkgo biloba extract groups were treated with Ginkgo biloba extract injections once a day after the operation. Each group of wistars was perfused and fixed at each time point. After putting them to death, basilar artery sections were taken and observed by conventional HE staining. Via the image analysis system, the arterial diameter and the vascular wall thickness were measured.

Result: After the treatment of Ginkgo biloba extract, the perimeter of the inner diameter of the basilar artery in 7 d treatment group was significantly larger than that in subarachnoid haemorrhage group (p<0.05). It was indicated by pathologic histology that the morphology of the spasm vessel had been improved.

Conclusion: Ginkgo biloba extract has a certain role in improving tardive cerebral angiospasm after wistar’s subarachnoid haemorrxhage.