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Effects of anti-osteoarthritic drugs on development of offspring of albino rats during pregnancy and lactation.

Esraa Khaled, Abd El Wahab El Ghareeb, Hamida Hamdi, Salwa Farouk

The present study aimed to evaluate the teratogenic effects of the anti-osteoarthritic drug (Genuphil) administered daily orally to the pregnant rats and nursing rats. The pregnant rats were treated during gestation and lactation with doses of 120 and 240 mg/kg. Histopathological studies of pregnant rats and their fetuses during gestation and lactation revealed few inflammatory cells infiltration in the portal area as well as in between the hepatocytes with dilatation in the portal vein, brown pigmented material in the periphery of the dilated central veins, oedema, congestion in the portal vein, granular degenerations in the hepatocytes in the liver. Degenerative change, swelling, coagulative necrosis, degeneration in the lining epithelium of the tubules, swelling of the glomeruli in the lining endothelium of the tufts and focal haemorrhage in between the degenerated tubules were observed in kidney of the treated groups while vacuolization and degeneration in the cerebrum were observed in the brain following Genuphil administration. Histopathological findings showed atritic follicles associated with proliferation of the interstitial stromal cells and severe congestion in the blood vessels of the medullary portion in the ovary while focal haemorrhage and necrosis in the giant cell layer detected in the placenta following Genuphil administration. Genuphil pre-treatment was able to decrease the level of lipid peroxidation while it increased the level of lipid peroxidation during gestation with only 240 mg/kg Genuphil and it decreased the GSH level. Our findings suggest the need for great caution to handle Genuphil especially during pregnancy and lactation.