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Estimation level of IL-10 and TNF-? in Iraq T1DM patient.

Sabreen Ali Mezil, Refif Sabih AL-Shawk

Tumor Necrosis Factor (TNF-α) also known as differentiation factor, is a key component in inflammatory and immune responses. TNF-α is a pleiotropic proinflammatory cytokine produced in response to infection, inflammation, and environmental stressors by activated macrophages, and lymphocytes. TNF-α has been shown to play a part in the autoimmune cascade that leads to beta cell death in type 1 diabetes, and repeated antibodymediated TNF-α action inhibition has been shown to protect non-obese mice from beta cell death. We tried to demonstrate a correlation between pro-inflammatory and anti-inflammatory cytokines including IL-10 and TNF-α, which are both involved in the pathogenesis of T1D, in children and adolescents under the age of 15 with varying diabetes durations in this study.