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Experimental hydatid cyst development in different breeds of mice: A reevaluation

Rafiei A, Asgarian F, Rahdar M, Jelowdar A, Sabaghan M

Cystic Echinococcosis (CE) is one of the most important zoonotic helminthic diseases throughout the world. Suitable and appropriate in vitro and in vivo situation are fundamental requirements for any investigations in the field of hydatidosis research. Three types of laboratory animals, Balb-c, NMRI and C57BL/6 female mice with age of 6 weeks were used as host for secondary larva development of Echinococcus granulosus by peritoneal injection. After 5 months all animals were dissected and were evaluated for existence of cyst infection in inguinal region, liver, lung, spleen, brain and muscle. The results have shown that 80% (eight of ten mice) secondary hydatid cyst growth among NMRI strain. The rate of infection in Balb-c was 90%. Most of the cysts were in subcutaneous, site of injection (10 mice). The rate of infection in C57BL/6 was 33.33% and just three of them were infected. There is no meaningful difference about the rate of infection between NMRI and Balb-c mouse, although the number and sum weight of cysts in the Balb-c strain were more than NMRI. Finally, both of NMRI and Balb-c strains can be considered as suitable animal models to produce secondary hydatid cyst.