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Glutathione S-transferase M1 polymorphism and the risk of pancreatitis

Minzhen Qin, Mengbin Qin, Zhihai Liang, Guodu Tang

Previous meta-analysis has found that no significant relationship between GSTM1 and chronic pancreatitis risk. However, we found a mistake in the abstract of the data in that meta-analysis. Additionally, new study was published. Thus, we conducted this meta-analysis. We did a systematic search of PubMed, EMBASE, Web of Science, and CNKI up to May 2017. We included 8 studies with 751 cases and 1614 controls in this meta-analysis. Subjects with GSTM1 null genotype were significantly associated with an increased risk for pancreatitis compared those carrying the GSTM1 present genotype (OR=1.17, 95% CI: 1.05-1.30). In addition, GSTM1 null genotype was significantly associated with chronic pancreatitis risk (OR=1.17, 95% CI: 1.05-1.30). Furthermore, Caucasians with GSTM1 null genotype showed an increased pancreatitis risk (OR=1.19, 95% CI: 1.06-1.32). In conclusion, this study indicated that GSTM1 null genotype were significantly associated with an increased risk for pancreatitis.