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Granulomatous Amebic Encephalitis (GAE): A severe disease.

Shawn Kruger

GAE caused by Acanthamoeba spp. is more common in chronically sick, debilitated people, immunocompromised people, such as those with HIV/AIDS, and people who have taken broad-spectrum antibiotics or chemotherapy drugs. Personality changes, headaches, low-grade fevers, nausea, vomiting, lethargy, diplopia, hemiparesis, seizures, decreased levels of awareness, and coma are some of the clinical symptoms. Some individuals may have palsies of the third and sixth cranial nerves. GAE might be mistaken for bacterial, tuberculous, or viral meningitis. GAE is more common in chronically sick, debilitated people, whether caused by Acanthamoeba spp. or B. mandrillaris. Many have had immunosuppressive therapy, have AIDS, or have been prescribed broad-spectrum antibiotics or chemotherapy drugs. The incubation time is unclear, and the sickness may take many weeks or months to manifest. Hematogenous invasion and penetration into the brain occurs as a result of dissemination from the original target, which is most likely the lower respiratory tract or the skin.