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Lactobacillus plantarum YS2 reduces oxazolone-induced colitis in BALB/c mice

Yu Qian, Ruokun Yi, Peng Sun, Guijie Li, Xin Zhao

By the animal model, the in vitro experiment anti-colitis effect of Lactobacillus plantarum YS2 (LPYS2) was measured. The BALB/c mice were induced colitis by oxazolone, and the serum and colon tissue levels were determined using kits and RT-PCR assay. The results showed that the DAI score of LP-YS2 treated mice was lower than control group. And the colon length and ratio of colon weight/colon length in colitis mice were also could be raised by LP-YS2 treatment. The MPO, NO, MDA colon tissue levels in LP-YS2 treated mice were higher than mice in control group, but GSH level was lower than control group mice. The cytokine levels of IL-2 in LP-YS2 treated mice was lower than mice in control group, but IL-10 level was higher than mice in control group. The nNOS, eNOS, c-Kit, SCF mRNA expressions in colon tissue of LP-YS2 treated mice were stronger than those in mice of control group, and iNOS, IL-8, CXCR2 expressions were weaker than those in mice of control group. From these results, LP-YS2 could be used as a probiotics which has anti-colitis effects.