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Significance of IL-15 in asthma pathogenesis

Sathisha Upparahalli Venkateshaiah

Immune-based diseases that are rising in prevalence jeopardize the health of the western world from the last decade [1,2]. In developing world 358 million people globally had asthma, 1990 [3]. A chronic inflammatory pulmonary disorder responsible for over 397,100 deaths in 2015 [4]. Asthma is one of these immune based chronic, inflammatory lung diseases characterized by variable airway obstruction, hyper responsiveness and remodelling [5-7]. Experimental research in the asthma field has largely focused on analysis of the cellular and molecular events induced by allergen exposure in sensitized animals and humans [8-12]. These research studies have been identified elevated production of IgE, mucus hyper secretion, and eosinophilic inflammation, which lead to lung function abnormalities and airway fibrosis [13-17]. Lung function abnormalities develop in chronic asthma disease and other chronic inflammatory processes on subsequent exposure to environmental inhalants such as allergens, organic and inorganic dusts, or autoimmune disease and sarcoidosis [18-23].