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Studies on the expression and relationship between MMP-9 and EGFR in laryngeal squamous cell carcinoma

Detao Ding

Objective: To discuss the expression and relationship between matrix metalloproteinase-9 and epidermal growth factor receptor in laryngeal squamous cell carcinoma.

Methods: Using the method of immunohistochemical to detect the matrix metalloproteinase-9 (MMP-9) and epithelial growth factor receptor (EGFR) in 58 cases of laryngeal squamous carcinoma tissues and 16 cases of normal laryngeal tissues of expression.

Results: MMP-9 in 58 cases of laryngeal squamous carcinoma tissue and EGFR positive expression rate is 68.9% and 77.6%, respectively, significantly higher than 16 cases of normal laryngeal tissue (P<0.05). MMP-9 and the expression of EGFR and tumour TNM stages, differentiate degree and lymph node metastasis (P<0.05). MMP-9, and the expression of EGFR was positively related to (chi-square=6.68, r=6.68, P<0.05). MMP-9 and EGFR is closely related to the prognosis of patients (P<0.05).

Conclusion: The expression of EGFR and the level of the expression of MMP-9 can be used as judgment index of laryngeal squamous carcinoma, malignant degree and prognosis.