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Study on CD4+CD25+Foxp3+T cells and clinical status of patients after renal transplantation

Bo Chen, Gai Hang, Yuan-Tao Wang, Zhi-Qiang Xu, Yu-Hong Feng, Chong-Sen Zang

Objective: To investigate the ratio change rule and its clinical meanings of peripheral CD4+CD25+Foxp3+T cells of patients under various immune status after renal transplantation.

Methods: This study involved 59 patients receiving renal transplantation who were assigned into stable kidney function group (n=20), acute rejection group (n=23), and pulmonary infection group (n=16), selected 18 healthy volunteers in control group and tested the change of peripheral T cell subsets of all participants with flow cytometry.

Results: The proportion of peripheral CD4+CD25+T cells, CD4+Foxp3+T cells, and CD4+CD25+Foxp3+T cells of patients in stable kidney function group was much lower than that in control group, with a statistical difference (P<0.05), but higher than that in acute rejection group and pulmonary group in which the ratio of CD4+CD25+T cells also exceeded that in the healthy group, having a significant difference (P<0.05).

Conclusion: Carefully monitoring the change of peripheral regulatory T cells of patients who underwent renal transplantation plays an essential role in preventing and treating post-renal transplantation rejection and local infection.