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Synergistic effect of curcumin, piperine and resveratrol in MCF-7 and MDA MB-231 breast cancer cells.

Betina Schmidt, Carlos Luan A Passos, Christian Ferreira, Jerson Lima da Silva, Eliane Fialho

Breast cancer is the type of cancer that kills more women in the world and the conventional cancer treatment has high costs and many side effects. The bioactive compounds from diet alone or in combination with others substances may be a potential source for the prevention and treatment of breast cancer. The aim was to investigate the effect of curcumin, piperine and resveratrol alone and associated in MCF-7 and MDA-MB-231 breast cancer cells culture. Curcumin, piperine and resveratrol showed cytotoxicity for MCF-7 and MDA-MB-231 cells with IC50 values of 24.50 μM, 94.50 μM and 131.00 μM, and 23.30 μM, 276.00 μM and 306.00 μM, respectively. The combination of curcumin+piperine, curcumin+resveratrol, piperine+resveratrol showed synergy in MCF-7 cells, and piperine+resveratrol in MDA-MB-231 cells. We conclude that the combination of bioactive compounds presents in diet as curcumin, piperine and resveratrol is better than used in isolated forms, and these results may be useful in future clinical trials with breast cancer.