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Synthesis and NAD(P)H: quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

Mostafa M. Ghorab, Abdelaaty A. Shahat, Mansour S. Alsaid, Maureen Higgins, Albena T. Dinkova-Kostova, Almoqbl A. Naser

Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses, ¹H -NMR and ¹³C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.