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The study of effect of hyperthyroidism on renal function

Sarita A. Shinde, Vaishali V. Dhat, Umesh K. More, Mona A. Tilak, Shikha Singh

Introduction: Thyroid dysfunction affects renal physiology and development, whereas kidney disease could result in thyroid dysfunction. A number of studies proved renal dysfunction in hypothyroidism but very few studies are available on hyperthyroidism. The aim of the present study is to see the impact of hyperthyroidism on kidney function.

Material and Methods: The present study included all 60 subjects. The control group comprising of 30 healthy age (25-45 years) and sex-matched subjects and the test group comprising of 30 clinically diagnosed hyperthyroidism patients (25-45 years). Thyroid Profile-T3, T4 and TSH are estimated by chemiluminescence immune assay. Renal profile- urea, creatinine and proteins are done by the kit method using autoanalyzer. Serum electrolytes were done by an AVL electrolyte analyzer. The estimated Glomerular Filtration Rate (eGFR) is calculated according to the formula recommended by the National Kidney Foundation using creatinine levels. The results were expressed as mean ± SD. And student’s unpaired ‘t’ tests were used for comparison the group.

Results: The statistically significant rise (P<0.05) in urea and decrease (P<0.05) in creatinine, total protein, and albumin concentration in hyperthyroidism as compared to the control group. It also shows a significant rise in the value of Egfr (P<0.05) and a nonsignificant reduction in serum electrolytes levels. Conclusion- The present study concluded that there is significant changes in renal function tests which reflect kidney dysfunction inpatient with hyperthyroidism.