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X-ray repair cross-complementing group 3 common polymorphism is not associated with cervical cancer risk

Yi Cao, Wei Chen, Yi Xia, Ge Zhao, Zheng Hu, Xin-Hua Xie

Recently, some reports investigated the association between X-ray Repair Cross-Complementing group 3 (XRCC3) and cervical cancer risk. However, the results were inconclusive. The meta-analysis, thus, assessed whether XRCC3 T241M polymorphism was associated with cervical cancer risk. Odds Ratios (ORs) with 95% Confidence Intervals (CIs) were calculated. Five case-control studies with a total of 806 cervical cancer cases and 850 controls were included. No association between XRCC3 T241M polymorphism and cervical cancer risk was found. In subgroup analysis, Asians with this polymorphism seemed to be associated with cervical cancer risk. Publication bias was not performed. In conclusion, this meta-analysis suggested that XRCC3 T241M polymorphism was not associated with cervical cancer risk.