சுருக்கம்

The transformed chymify-carcinoma pancreas.

Anubha Bajaj*

Carcinoma pancreas emerges from diverse pancreatic cells wherein pancreatic adenocarcinoma is preponderantly (~90%) discerned with mutations within KRAS, CDKN2A, TP53 AND SMAD4 genes. Smoking, obesity, type 2 diabetes mellitus, type 3c or pancreatogenic diabetes, excessive alcohol intake, chronic pancreatitis, hereditary pancreatitis, family history of carcinoma pancreas, consumption of processed or red meat and certain genetic profiles predispose to occurrence of carcinoma pancreas. Carcinoma pancreas manifests with anorexia, unexplained weight loss, indigestion, upper abdominal or back pain, jaundice, compression of adjacent organs, altered gastric emptying, nausea, vomiting, steatorrhoea, constipation, new onset type 2 diabetes mellitus, palpable abdominal mass or preceding pancreatitis.

Adenocarcinoma pancreas demonstrates moderate to poorly differentiated glandular articulations with significant desmoplasia or dense, fibrotic stroma. Computerized Tomography (CT) or endoscopic ultrasound (EUS) can be employed to confirm carcinoma pancreas. Surgical resection can appropriately alleviate pancreatic adenocarcinoma although prognostic outcomes are inferior.