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Two long-term follow-up cases about adefovir-induced hypophosphatemic osteomalacia

Ying Zhang, Fang Ji, Jun-Gui Hao and Xue-Bing Yan

Adefovir dipivoxil is widely used in the treatment of chronic hepatitis B patients. Nephrotoxicity manifesting was frequently reported when higher doses of adefovir dipivoxil were used to treat the person who was infected with human immunodeficiency virus in the past. However, kidney diseases in the proximal kidney tubule can caused by using adefovir dipivoxil with a low dose. We encountered two patients who underwent systemic bone pain associated with adefovir dipivoxilinduced hypophosphatemic osteomalacia. So far, we have followed them for 8 years and found that longterm use of adefovir dipivoxil could cause chronic kidney damage.