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Anti-hyperglycemic effect of Salvadora persica leaf extracts in alloxanized rats

Alrasheedi AA, Hijazi MA

In this study thirty-five male albino rats weighing 170-190 g (two months age). Were used to evaluating the Anti-hyperglycemic effect of Salvadora persica leaf extract in hyperglycemic rats induced by alloxan in addition to its effects on kidney functions, lipids profile, and hepatic functions. These rats were fed on the standard diet for two weeks to adjust before the experiment began; Rats were separated into five groups. Each group contains seven rats. The healthy control rats (Group 1) were fed on the standard diet. The (group 2), (group 3), (group 3) and (group 5) were injected with one dose of alloxan monohydrate at (150 mg per kg of body weight). The hyperglycemic control rats (group 2) were fed on standard diet. The hyperglycemic rats for group 3, group 4 and group 5 were treated with leaf extract of Salvadora persica orally at 50,100 and 150 mg/kg of body weight per day for six weeks respectively. From the results of present work indicate that, the hyperglycemic rats untreated with Salvadora persica leaf extracts (group 2) showed increased in serum glucose levels, glycosylated hemoglobin (HbA1c), cholesterol, triglycerides, total lipids, (LDL-c) low density lipoprotein, (VLDL-c) very low density lipoprotein, renal function, Serum, (AST) aspartate aminotransferase activity and (ALT) alanine aminotransferase and decreased in insulin and (HDL-c) high density lipoprotein relative to healthy control rats (group 1). Treating the hyperglycemic rats in group 3, group 4 and group 5 with leaf extract of Salvadora persica were improved the histological and biochemical changes nearly to the healthy rats (group 1).