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Various mechanisms of Quercetin on inhibiting breast cancer growth: a mini-review

Fatemeh Yaghoubi, Ali Moradi

Breast cancer is the second leading cause of death among women after lung cancer. Although chemotherapy is the most common therapeutic strategy for the treatment of breast cancer, its side effects are always a major obstacle in cancer treatment. Quercetin is a flavonoid compound abundantly found in fruits and vegetables, and it has been proven to possess anti-cancer potential in breast cancer. Quercetin, through several mechanisms, exerts its anti-tumor properties, including the cell cycle arrest at G1 and/or G2/M, inhibition of the signal transduction pathways in cancer cells, regulation of growth factors to prevent cell proliferation, and the induction of apoptosis. This article reviews the molecular mechanisms of quercetin in the elimination of breast cancer cell lines.